Embryo-feto-toxicity of Anticancer Drug, Heptaplatin in Laboratory Mice
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چکیده
منابع مشابه
Evaluation of Fetal Toxicity of HESA-A, a Natural Anticancer Agent, in Mice
Introduction: HESA-A is an active natural compound with herbal and marine origin. It contains inorganic, organic and aqueous fractions, and has shown antioxidant, cytotoxic and anticancer effects. In this study, the teratogenic effects of HESA-A in mice have been evaluated. Methods: Several doses of HESA-A were administered orally to pregnant mice on days 6 to 14 of gestation. Various parameter...
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Mycoplasma are small, cell-free bacteria enclosed by a membrane. These bacteria belong to the class of Mollicutes, the order of Mycoplasma tales, and the genus of Mycoplasma. There are more than 100 identified species of mycoplasma. The ratio of cytosine to guanine in its DNA is 23–40% and its genome size is 1350–600 kb. Mycoplasma require cholesterol to grow, and the temperature su...
متن کاملATTENUATION OF PARAQUAT TOXICITY IN MICE
Paraquat (PQ) is a widely used herbicide. However, a large number of cases of accidental or suicidal poisoning from PQ has been reported. Membrane damage induced by lipid peroxidation, inactivation of protein or damage to DNA by radical formation have been suggested as toxicity mechanisms of PQ. In the present work, the effects of atropine, propranolol, procainamide and dipyridamole on PQ-...
متن کاملP-84: Protective Effect of Black Grapes Seed Hydroalcholic Extract Against Fluoxetine-Induced Embryo Toxicity in Male Mice
Background: Fluoxetine (FLX) is a selective serotonin reuptake inhibitors antidepressant. FLX affects chemicals in the brain that may become unbalanced and cause depression, panic, anxiety, or obsessive-compulsive symptoms. Black Grape seed extract (BGSE) antioxidants neutralize free radicals and oxidative stress. Therefore this study was designed to investigate Protective effect of RGSE hydroa...
متن کاملThe role of lysosomes in limiting drug toxicity in mice.
The distribution behavior of a drug within a cell is an important, yet often overlooked, variable in both activity and differential selectivity. In normal cells, drugs with weakly basic properties are known to be extensively compartmentalized in acidic organelles such as lysosomes via ion trapping. Several cancer cell lines have been shown to have defective acidification of endocytic organelles...
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ژورنال
عنوان ژورنال: Pakistan Journal of Biological Sciences
سال: 2010
ISSN: 1028-8880
DOI: 10.3923/pjbs.2010.896.900